TDM may refer to:

• TDM, a 2023 Indian Marathi comedy film
• TDM (Macau) (Teledifusão de Macau), a Macanese radio and television network
• The Yamaha TDM, a motorcycle model
• Target Disk Mode, a boot mode on certain Macintosh computers
• Team deathmatch, a mode of gameplay in video games
• Technical death metal, a subgenre of heavy metal music
• Telecomunicações de Moçambique, a Mozambican telecommunications and Internet service provider
• Teresian Daughters of Mary, a Filipino Roman Catholic institute
• Text data mining, a process of deriving high-quality information from text
• The Difference Machine, an album by English rock band Big Big Train
• Therapeutic drug monitoring, a branch of clinical chemistry
• Time-division multiplexing, a method of transmitting and receiving independent signals over a common signal path
• Toad Data Modeler, a database design tool
• Transportation demand management, also traffic demand management or travel demand management
• DanTDM, British YouTube personality